UGT1A6
The UGT1A6 Gene: Unraveling Its Role in Detoxification and Disease
Introduction
Nestled within our genetic blueprint lies a crucial gene known as UGT1A6. This gene plays a pivotal role in the body‘s detoxification processes and has been linked to a wide range of diseases.
Description
The UGT1A6 gene encodes an enzyme called UDP-glucuronosyltransferase 1A6, which is responsible for adding glucuronic acid to various molecules. This process, known as glucuronidation, is a major detoxification pathway in the body. By attaching glucuronic acid to molecules, UGT1A6 helps make them more water-soluble and easier to excrete.
Associated Diseases
Defects or variations in the UGT1A6 gene have been associated with several diseases, including:
- Crigler-Najjar syndrome: A rare liver disorder characterized by severe jaundice in infants.
- Gilbert‘s syndrome: A common liver disorder that causes mild, intermittent jaundice.
- Irinotecan toxicity: Increased risk of severe side effects from the chemotherapy drug irinotecan.
- Chronic cholestasis: A condition that causes bile to build up in the liver, leading to liver damage.
Did you Know ?
Approximately 1 in 3 Asians carry a genetic variant in the UGT1A6 gene that reduces its activity. This variant is associated with an increased risk of side effects from irinotecan and other drugs that are metabolized by UGT1A6.
