UBXN2A
Description
The UBXN2A (UBX domain protein 2A) is a protein-coding gene located on chromosome 2.
UBXN2A is a protein that plays a role in regulating protein degradation and trafficking. It is involved in the degradation of CHRNA3, the translocation of CHRNA3 to the plasma membrane, and the inhibition of TP53 degradation.
UBXN2A, also known as UBXN4, plays a role in regulating protein degradation and trafficking. It prevents the degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons, promoting CHRNA3 translocation to the plasma membrane and enhancing acetylcholine-gated ion-channel activation. UBXN2A also inhibits STUB1-mediated degradation of TP53 by interacting with HSPA9, preventing TP53 binding to HSPA9. Additionally, UBXN2A promotes the ubiquitination and proteosomal degradation of RICTOR, potentially acting as a negative regulator of the mTORC2 pathway. These activities are mediated through interactions with various proteins, including CHRNA3, VCP/P97, HSPA9/MOT-2, and RICTOR, utilizing distinct domains such as the SEP, UBX, and SBD domains.
UBXN2A is also known as UBXD4.
