UBE2C
Description
The UBE2C (ubiquitin conjugating enzyme E2 C) is a protein-coding gene located on chromosome 20.
UBE2C is a protein involved in the tagging of proteins for destruction through a process called ubiquitination. This process uses three main types of enzymes: E1, E2, and E3. UBE2C belongs to the E2 family of enzymes. This protein is essential for breaking down mitotic cyclins, proteins that regulate cell division, and for the progression of the cell cycle. Several different forms of the gene that encodes UBE2C have been found, but the complete structure of some of these forms is unknown.
UBE2C receives ubiquitin from the E1 complex and attaches it to other proteins. It can create both 'Lys-11' and 'Lys-48' linked polyubiquitin chains in laboratory settings. UBE2C is crucial for the anaphase-promoting complex/cyclosome (APC/C), a protein complex that regulates cell division by marking proteins for degradation. Specifically, UBE2C starts the formation of 'Lys-11' linked polyubiquitin chains on APC/C target proteins. This ultimately leads to the breakdown of these targets by the proteasome, allowing cells to complete mitosis.
UBE2C is also known as UBCH10, dJ447F3.2.
