TYR


Description

The TYR gene, located on chromosome 11, holds the blueprint for the enzyme tyrosinase. This enzyme is crucial for the production of melanin, the pigment responsible for skin, hair, and eye color. Tyrosinase catalyzes the initial steps in melanin synthesis, converting tyrosine to DOPAquinone, which ultimately leads to the formation of eumelanin (brown/black pigment) and pheomelanin (red/yellow pigment). Variations in the TYR gene can influence melanin production, affecting pigmentation and susceptibility to certain conditions.

Associated Diseases

Did you know?

The TYR gene‘s role in pigmentation is evident in animals too. For example, Siamese cats have a mutation in the TYR gene that reduces tyrosinase activity, leading to their distinctive darker coloration in cooler areas of their body.


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