TYK2
Description
The TYK2 gene encodes a protein tyrosine kinase, TYK2, which plays a crucial role in immune system regulation. It acts as a signaling molecule, mediating the activation of immune cells in response to various cytokines, including interferons and interleukins. TYK2 is involved in both innate and adaptive immune responses, contributing to the development of immune cells, the production of antibodies, and the control of inflammation.
Associated Diseases
- Autoimmune disorders: Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), psoriasis, multiple sclerosis (MS)
- Primary immunodeficiency: Severe combined immunodeficiency (SCID)
- Cancer: Certain types of leukemia and lymphoma
Did you know?
Mutations in the TYK2 gene can cause a rare primary immunodeficiency disorder called "autosomal recessive severe combined immunodeficiency (SCID)", making individuals highly susceptible to infections.
