TXNIP
Description
The TXNIP (thioredoxin interacting protein) is a protein-coding gene located on chromosome 1.
Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.
== Interactions == TXNIP has been shown to interact with Thioredoxin and ZBTB32.
TXNIP acts as an oxidative stress mediator by inhibiting thioredoxin activity or limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. TXNIP is required for the maturation of natural killer cells. It acts as a suppressor of tumor cell growth. It inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
TXNIP is also known as ARRDC6, EST01027, HHCPA78, THIF, VDUP1.
