TUSC5
The Intriguing World of the TUSC5 Gene: Unveiling its Role in Health and Disease
Description
The TUSC5 gene, located on chromosome 16, encodes a protein known as tumor suppressor candidate 5. This pivotal gene plays a critical role in suppressing tumor growth and maintaining cellular homeostasis. It exerts its influence through various mechanisms, including regulating cell cycle progression, DNA repair, and apoptosis (programmed cell death).
Associated Diseases
Mutations in the TUSC5 gene have been linked to several diseases, including:
- Pancreatic cancer: TUSC5 mutations are commonly observed in pancreatic tumors, where they contribute to uncontrolled cell proliferation and tumor formation.
- Lung cancer: TUSC5 alterations are associated with increased risk of lung cancer development, particularly in smokers.
- Liver cancer: TUSC5 mutations have been implicated in the progression of liver cancer, promoting tumor growth and metastasis.
- Other cancers: TUSC5 alterations have also been detected in a variety of other cancers, such as breast, colorectal, and gastric cancers.
Did you Know ?
A recent study revealed that mutations in the TUSC5 gene are found in approximately 10% of pancreatic cancer cases. This alarming statistic highlights the significant role of TUSC5 in the development and progression of this deadly disease.
