TUSC2

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Description

The TUSC2 (tumor suppressor 2, mitochondrial calcium regulator) is a protein-coding gene located on chromosome 3.

The TUSC2 gene encodes a highly conserved protein, Tumor suppressor candidate 2, which is implicated in lung cancer. Limited information is currently available about this gene.

TUSC2 may act as a tumor suppressor by preventing the formation of new cell colonies, halting cell division in the G1 phase, and ultimately leading to programmed cell death in cells lacking the 120-kb region on chromosome 3p21.3.

TUSC2 is also known as C3orf11, FUS1, PAP, PDAP2.

Associated Diseases

• cancer
• autoimmune lymphoproliferative syndrome
• autoinflammatory syndrome with immunodeficiency
• Li-Fraumeni syndrome
• DDX41-related hematologic malignancy predisposition syndrome
• systemic lupus erythematosus
• autoimmune lymphoproliferative syndrome type 2A
• chilblain lupus
• autoimmune lymphoproliferative syndrome type 4
• VEXAS syndrome
• Wiskott-Aldrich syndrome
• autosomal systemic lupus erythematosus type 16