TUBA1B
Description
The TUBA1B (tubulin alpha 1b) is a protein-coding gene located on chromosome 12.
TUBA1B is a gene that encodes the protein Tubulin alpha-1B chain. This protein interacts with PIK3R1. Antibodies against Tubulin alpha 1b can be used as markers for microtubules and spindles.
Tubulin, a key protein found in microtubules, forms cylinders made up of linear protofilaments. These protofilaments are composed of alpha- and beta-tubulin heterodimers. Microtubules grow by adding GTP-tubulin dimers to their ends, where a stabilizing cap forms. Below this cap, tubulin dimers bind GDP due to the GTPase activity of alpha-tubulin.
TUBA1B is also known as K-ALPHA-1.
Associated Diseases
- lung cancer
- breast cancer
- fallopian tube neoplasm
- malignant epithelial tumor of ovary
- neutropenia
- urinary bladder cancer
- primary peritoneal carcinoma
- thyroid cancer
- fallopian tube clear cell adenocarcinoma
- fallopian tube endometrioid adenocarcinoma
- head and neck carcinoma
