TTLL6
Description
The TTLL6 (tubulin tyrosine ligase like 6) is a protein-coding gene located on chromosome 17.
TTLL6 is an enzyme that adds a chain of glutamate molecules to other proteins, including both tubulin and non-tubulin proteins. It prefers to add long chains of glutamate, rather than starting new chains. It also favors adding these chains to the alpha-tubulin tail, rather than the beta-tail. This modification of tubulin helps to regulate microtubule function by stimulating the breakdown of microtubules by spastin. TTLL6 also plays a role in the formation and movement of cilia by adding glutamate chains to the microtubules in these structures. Additionally, TTLL6 can modify the protein CGAS, which helps to prevent the immune system from responding to viral infections.
TTLL6 is also known as TTL.6.
Associated Diseases
- hyperinsulinism due to INSR deficiency
- exercise-induced hyperinsulinism
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
- glycogen storage disorder due to hepatic glycogen synthase deficiency
