TTLL2
Description
The TTLL2 (tubulin tyrosine ligase like 2) is a protein-coding gene located on chromosome 6.
TTLL2 is a probable tubulin polyglutamylase that adds glutamate side chains to specific glutamate residues in the C-terminal tail of target proteins. It likely requires other proteins to become enzymatically active, suggesting it lacks domains necessary for independent activity. TTLL2 is thought to initiate the polyglutamylation reaction rather than elongate existing chains.
TTLL2 is also known as C6orf104, NYD-TSPG, dJ366N23.3.
