TTC25
The ttc25 Gene: A Key Player in Male Fertility
Description
The ttc25 gene is located on chromosome 2 and encodes a protein called TTC25, which plays a crucial role in the formation and function of sperm cells (spermatogenesis). TTC25 is required for the proper assembly and function of the outer membrane of the sperm's head, known as the acrosome. The acrosome contains enzymes that are essential for the sperm to penetrate the egg's protective layer during fertilization.
Associated Diseases
Mutations in the ttc25 gene have been linked to male infertility. These mutations can impair the formation of the acrosome, disrupt sperm function, and result in reduced fertility or complete infertility. TTC25 mutations account for approximately 1-2% of all cases of male infertility.
Did you Know ?
According to the American Urological Association, up to 15% of couples experience infertility, and male factors contribute to about half of these cases. The ttc25 gene mutation is one of the most common genetic causes of male infertility, affecting an estimated 1 in 1,000 men.
