TST

Description

The TST (thiosulfate sulfurtransferase) is a protein-coding gene located on chromosome 22.

TST, a human gene, can refer to Thiosulfate sulfurtransferase, a protein also known as Rhodanese. It plays a role in forming iron-sulfur complexes, detoxifying cyanide, and modifying sulfur-containing enzymes. TST can accept sulfur ions from various thiol compounds, including cyanide. It also exhibits weak mercaptopyruvate sulfurtransferase (MST) activity. Together with MRPL18, TST acts as a mitochondrial import factor for cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form of TST can bind to 5S rRNA. TST exists as a monomer.

TST is also known as RDS.

Associated Diseases

• 46,XY complete gonadal dysgenesis
• isolated congenital hypogonadotropic hypogonadism
• hemoglobin D disease
• tetragametic chimerism
• 46,XX ovotesticular disorder of sex development
• 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
• 46,XX testicular disorder of sex development
• partial chromosome Y deletion
• Leydig cell hypoplasia