TSSK3
Tssk3 Gene: A Key Player in Health and Disease
Description
The Tssk3 gene, located on chromosome 12, encodes a protein called tescalcin, which plays a crucial role in several biological processes, including cell growth, differentiation, and immune function. Tescalcin is secreted by various cell types, including endothelial cells, and is involved in regulating vascular development and tissue remodeling.
Associated Diseases
Dysregulation of the Tssk3 gene has been linked to several diseases, including:
- Cancer: Overexpression of Tssk3 has been observed in various types of cancer, including lung, breast, and prostate cancer. It is believed to promote tumor growth, metastasis, and angiogenesis (the formation of new blood vessels in tumors).
- Autoimmune diseases: Tssk3 plays a role in regulating the immune system. Mutations in the Tssk3 gene have been associated with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE).
- Cardiovascular diseases: Tssk3 is involved in vascular development and remodeling. Alterations in Tssk3 expression have been linked to cardiovascular diseases such as atherosclerosis and hypertension.
- Neurological disorders: Tescalcin has neuroprotective properties. Reduced Tssk3 expression has been associated with neurodegenerative disorders such as Alzheimer's disease.
Did you Know ?
Research has shown that individuals with a single nucleotide polymorphism (SNP) in the Tssk3 gene are at a significantly increased risk of developing lung cancer. This SNP alters the amino acid sequence of tescalcin, potentially affecting its function and leading to cancer development.
