TSPAN5


Description

The TSPAN5 (tetraspanin 5) is a protein-coding gene located on chromosome 4.

TSPAN5, also known as Tetraspan NET-4 or Transmembrane 4 superfamily member 9, belongs to the TspanC8 subgroup, which comprises six members that interact with the transmembrane metalloprotease ADAM10. This interaction is crucial for ADAM10's exit from the endoplasmic reticulum, its enzymatic maturation, trafficking to the cell surface, and substrate specificity. The different TspanC8/ADAM10 complexes exhibit distinct substrate preferences. TSPAN5 promotes ADAM10-mediated cleavage of CD44 and appears to regulate VE-cadherin expression in endothelial cells, potentially through interaction with ADAM10, facilitating leukocyte transmigration.

TSPAN5 is also known as NET-4, NET4, TM4SF9, TSPAN-5.

Associated Diseases



Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.