TSIX

Description

The TSIX (TSIX transcript, XIST antisense RNA) is a ncRNA gene located on chromosome X.

TSIX, also known as XIST antisense, is a long non-coding RNA gene that plays a vital role in regulating X chromosome inactivation (XCI). It is transcribed from the X-inactivation center (Xic) on the X chromosome and acts as an antagonist of XIST. This means it prevents the spreading and silencing of XIST on the active X chromosome, ensuring that only one X chromosome is inactivated in females.

TSIX is a long non-coding RNA (lncRNA) that acts as a crucial regulator of X chromosome inactivation (XCI). It is transcribed from the X-inactivation center (Xic) and plays a vital role in determining which X chromosome will be silenced in female mammals. TSIX functions as an antagonist of XIST, another lncRNA involved in XCI. By directly interacting with XIST, TSIX prevents its spreading and silencing of the active X chromosome. This antagonistic relationship ensures that only one X chromosome is inactivated in females, maintaining dosage compensation for X-linked genes.

TSIX is also known as LINC00013, NCRNA00013, XIST-AS, XIST-AS1, XISTAS.

Associated Diseases

• breast cancer
• systemic lupus erythematosus
• Turner syndrome
• breast angiosarcoma
• multiple sclerosis
• Rett syndrome
• cancer