TSHR

Description

The TSH Receptor (TSHR) gene plays a crucial role in thyroid hormone regulation. It encodes a protein found on the surface of thyroid cells, acting as a receptor for thyroid-stimulating hormone (TSH). TSH, secreted by the pituitary gland, binds to the TSHR, triggering a cascade of events leading to the production and release of thyroid hormones (T3 and T4) into the bloodstream. These hormones are essential for growth, development, and metabolism. Mutations in the TSHR gene can disrupt this intricate process, leading to various thyroid disorders.

Associated Diseases

• Graves‘ disease
• Hashimoto‘s thyroiditis
• Congenital hypothyroidism
• Thyroid cancer
• Resistance to thyroid hormone

Did you know?

The TSHR gene is a prime target for autoimmune attacks, leading to hyperthyroidism in Graves‘ disease and hypothyroidism in Hashimoto‘s thyroiditis.