TSC22D3
Description
The TSC22D3 (TSC22 domain family member 3) is a protein-coding gene located on chromosome X.
TSC22 domain family protein 3 is a protein encoded by the TSC22D3 gene in humans. It shares sequence similarity with the murine TSC-22 and Drosophila shs proteins, which are leucine zipper proteins known to function as transcriptional regulators. TSC22D3 is expressed in various tissues, including the thymus, spleen, lung, fat, liver, kidney, heart, and skeletal muscle. Its expression is stimulated by glucocorticoids and interleukin 10, suggesting a role in the anti-inflammatory and immunosuppressive effects of these molecules. The gene produces different isoforms of the protein. TSC22D3 interacts with C-Raf, NFKB2, and NFKB1.
TSC22D3 protects T-cells from apoptosis caused by IL2 deprivation by inhibiting FOXO3A's transcriptional activity, which reduces the expression of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, it contributes to the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, TSC22D3 blocks the nuclear translocation of NFKB1 triggered by anti-CD3, thereby inhibiting its DNA-binding activities (PubMed:11468175). It also suppresses the DNA-binding activities of the AP-1 transcription factor complex in vitro.
TSC22D3 is also known as DIP, DSIPI, GILZ, TSC-22R.
Associated Diseases
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failures 50
- spermatogenic failure 25
- isochromosomy Yp
- spermatogenic failure, X-linked, 2
- congenital bilateral absence of vas deferens
- isochromosomy Yq
- spermatogenic failure 74
- spermatogenic failure 73
- spermatogenic failure 61
- spermatogenic failure 48
- spermatogenic failure 44
- spermatogenic failure 63
- spinocerebellar ataxia type 32
