TSC22D1
Description
The TSC22D1 (TSC22 domain family member 1) is a protein-coding gene located on chromosome 13.
TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene. TSC22 encodes a transcription factor and belongs to the large family of early response genes. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.
TSC22D1 acts as a transcriptional repressor and plays a role in regulating apoptosis, TGF-beta signaling, and hematopoietic cell growth. It interacts with various proteins, including SMAD7, SMAD4, TFE3, and TPT1/fortilin, to modulate these processes. Specifically, it promotes TGF-beta signaling by interacting with SMAD7 and inhibiting its binding to TGFBR1, thereby preventing the degradation of TGFBR1. It also enhances TGF-beta signaling by interacting with and modulating the activity of SMAD4. Furthermore, TSC22D1 promotes TGF-beta-induced transcription of COL1A2 by interacting with TFE3 at E-boxes in the gene's promoter. Notably, TSC22D1 promotes IL2 deprivation-induced apoptosis in T-lymphocytes by repressing TSC22D3/GILZ transcription and activating the caspase cascade. In addition, it acts on the C-type natriuretic peptide (CNP) promoter and promotes CASP3-mediated apoptosis.
TSC22D1 is also known as HUCEP-2, Ptg-2, TGFB1I4, TSC22.
