TRPM3

Description

The TRPM3 (transient receptor potential cation channel subfamily M member 3) is a protein-coding gene located on chromosome 9.

TRPM3, encoded by the TRPM3 gene, belongs to the family of transient receptor potential (TRP) channels, which are calcium-permeable non-selective cation channels involved in various physiological processes, including calcium signaling, heat and cold sensation, and calcium and magnesium homeostasis. TRPM3 allows sodium and calcium to enter cells, causing depolarization and a cytoplasmic calcium signal. Different isoforms of TRPM3 are produced due to alternative splicing. TRPM3 is activated by the neurosteroid pregnenolone sulfate and the synthetic compound CIM0216. TRPM3 is found in sensory neurons of the dorsal root ganglia and is activated by high temperatures. Removing TRPM3 in mice reduces their sensitivity to painful heat and inflammatory heat hypersensitivity. TRPM3 inhibitors also decrease painful heat and inflammatory heat hypersensitivity, as well as heat hypersensitivity and spontaneous pain caused by nerve damage. TRPM3 is strongly inhibited when cell surface receptors, linked to inhibitory heterotrimeric G-proteins (Gi) via direct binding of the Gβγ subunit of the G-protein, are activated.

TRPM3 is also known as CTRCT50, GON-2, LTRPC3, MLSN2, NEDFSS.

Associated Diseases

• Cataract 50 with or without glaucoma
• Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skeletal anomalies, with or without seizures