TRPC5

Description

The TRPC5 (transient receptor potential cation channel subfamily C member 5) is a protein-coding gene located on chromosome X.

TRPC5, also known as Transient receptor protein 5, is a member of the TRPC family of mammalian transient receptor potential ion channels. It forms a multi-pass membrane protein and functions as a receptor-activated, non-selective calcium permeable cation channel. TRPC5 can be active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It interacts with several proteins, including calmodulin, CABP1, enkurin, NHERF, MX1, RNF24, and SESTD1. TRPC4 and TRPC5 are implicated in mercury toxicity and neurological behavior. TRPC5 is a component of the dental cold sensing system. TRPC5 is activated by extracellular reduced thioredoxin and is also involved in the action of anesthetics like chloroform, halothane, and propofol.

TRPC5 is thought to function as a receptor-activated non-selective calcium permeant cation channel. It is likely activated by a phosphatidylinositol second messenger system, triggered by receptor tyrosine kinases or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective and may be activated by intracellular calcium store depletion. It mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons through its interaction with PLSCR1.

TRPC5 is also known as PPP1R159, TRP5.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing