TRPC4AP
Description
The TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein) is a protein-coding gene located on chromosome 20.
Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.
TRPC4AP is a substrate-recognition component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, which is essential for cell cycle control. This complex specifically targets MYC for polyubiquitination and degradation as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND pathway recognizes a C-degron at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, triggering their ubiquitination and degradation. TRPC4AP also participates in the activation of NFKB1 in response to TNFRSF1A ligation, potentially by connecting TNFRSF1A to the IKK signalosome. Additionally, it plays a role in JNK activation through its interaction with TRAF2. TRPC4AP is also involved in the reduction of endoplasmic reticulum Ca(2+) storage in response to CHRM1. {ECO:0000250|UniProtKB:Q9JLV2, ECO:0000269|PubMed:20551172, ECO:0000269|PubMed:29779948}
TRPC4AP is also known as C20orf188, PPP1R158, TRRP4AP, TRUSS.
