TRNP1
Description
The TRNP1 (TMF1 regulated nuclear protein 1) is a protein-coding gene located on chromosome 1.
TRNP1 (TMF-regulated nuclear protein 1) is a nuclear protein crucial for cellular proliferation and brain development. It's the first protein identified to play a major role in cortical folding and is a key stem cell factor involved in brain and stem cell development. TRNP1 controls gene expression levels and can induce gyri and sulci in the developing brain. Variations in TRNP1 expression levels in the human brain are linked to cortical folding. TRNP1 binds to DNA with high affinity, though its exact molecular function is unknown. It lacks known molecular motifs, suggesting a novel class of molecules. TRNP1 significantly enhances cellular proliferation in vitro and in vivo. Beyond its role in brain development, TRNP1 might also play a significant role in cancer cells, as it has been identified in gene expression analyses of various cancer types.
TRNP1 is also known as C1orf225, TNRP, TRNP.
