TRNAU1AP
Description
The TRNAU1AP (tRNA selenocysteine 1 associated protein 1) is a protein-coding gene located on chromosome 1.
TRNAU1AP plays a critical role in the biosynthesis of selenocysteine and its incorporation into selenoproteins. It participates in the early stages of selenocysteine synthesis and the charging of tRNA(Sec) with selenocysteine, ultimately leading to the cotranslational integration of selenocysteine into selenoproteins. Additionally, TRNAU1AP stabilizes the complex formed by SECISBP2, EEFSEC, and tRNA(Sec), suggesting a role in the regulation of selenocysteine incorporation. It may also contribute to the methylation of tRNA(Sec), potentially influencing its function and stability. Furthermore, TRNAU1AP appears to enhance the efficiency of selenoprotein synthesis.
TRNAU1AP is also known as PRO1902, SECP43, TRSPAP1.
