TRMT2A

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Description

The TRMT2A (tRNA methyltransferase 2 homolog A) is a protein-coding gene located on chromosome 22.

TRMT2A is an S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs. It primarily methylates uridine at position 54 (m5U54) in cytosolic tRNAs, but can also mediate the formation of 5-methyl-uridine in specific mRNAs.

TRMT2A is also known as HTF9C.

Associated Diseases

• transient myeloproliferative syndrome
• pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9
• reticular dysgenesis
• cancer
• clubfoot
• COVID-19