TRIP10
Description
The TRIP10 (thyroid hormone receptor interactor 10) is a protein-coding gene located on chromosome 19.
TRIP10 is a human gene that encodes the Cdc42-interacting protein 4.
TRIP10 plays a crucial role in insulin signaling by facilitating the translocation of GLUT4 to the plasma membrane. It also coordinates membrane tubulation with actin cytoskeleton reorganization during endocytosis. TRIP10 binds to lipids like phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, promoting membrane invagination and tubule formation. It further promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP, activating the Arp2/3 complex. This actin polymerization contributes to the fission of membrane tubules into endocytic vesicles. TRIP10 is essential for the formation of podosomes, specialized actin-rich adhesion structures found in monocyte-derived cells. It might also be involved in the lysosomal retention of FASLG/FASL.
TRIP10 is also known as CIP4, HSTP, STOT, STP, TRIP-10.
Associated Diseases
- isolated agammaglobulinemia
- severe combined immunodeficiency due to CARD11 deficiency
- hyper-IgM syndrome type 3
- common variable immunodeficiency
- BENTA disease
- hyper-IgM syndrome type 5
- hyper-IgM syndrome type 2
- autoimmune lymphoproliferative syndrome type 2B
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- classic Hodgkin lymphoma
