TRIM62

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Description

The TRIM62 (tripartite motif containing 62) is a protein-coding gene located on chromosome 1.

TRIM62, also known as DEAR1 (for ductal epithelium–associated RING chromosome 1), is a protein belonging to the tripartite motif family. It is encoded by the TRIM62 gene in humans. TRIM62 is involved in mammary gland development, and its loss of expression in breast cancer is linked to a higher risk of recurrence in early-onset cases.

TRIM62 acts as an E3 ubiquitin ligase in antifungal immunity. It specifically ubiquitinates CARD9 at Lys-27, a process triggered by C-type lectin receptors. This ubiquitination activates CARD9, subsequently activating the NF-kappa-B and MAP kinase p38 pathways. TRIM62's E3 ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D2.

TRIM62 is also known as DEAR1.

Associated Diseases

• epidermodysplasia verruciformis
• myofibromatosis, infantile, 1
• BAP1-related tumor predisposition syndrome
• familial atypical multiple mole melanoma syndrome
• colorectal cancer, susceptibility to, 12
• Ollier disease
• attenuated familial adenomatous polyposis
• Maffucci syndrome
• Li-Fraumeni syndrome
• lung cancer
• extraskeletal myxoid chondrosarcoma
• disseminated superficial actinic porokeratosis