TRIM6
Description
The TRIM6 (tripartite motif containing 6) is a protein-coding gene located on chromosome 11.
TRIM6 is a protein encoded by the TRIM6 gene in humans. It belongs to the tripartite motif (TRIM) family, characterized by three zinc-binding domains (RING, B-box type 1, and B-box type 2) and a coiled-coil region. TRIM6 is located in the nucleus, but its specific function remains unknown. The gene is found on chromosome 11p15 within a TRIM gene cluster. Two alternatively spliced transcript variants have been identified, encoding distinct isoforms. Additionally, a read-through transcript transcribed from both TRIM6 and TRIM34 has been observed.
TRIM6 is an E3 ubiquitin ligase that plays a crucial role in activating the IKBKE-dependent branch of the type I interferon signaling pathway. It works with the ubiquitin-conjugating E2 enzyme UBE2K to create unanchored 'Lys-48'-linked polyubiquitin chains. These chains promote the oligomerization and autophosphorylation of IKBKE, triggering an antiviral response. TRIM6 also ubiquitinates MYC, inhibiting its transcription activation activity and maintaining the pluripotency of embryonic stem cells. Additionally, it enhances the RIGI-mediated innate antiviral immune response by promoting the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16.
TRIM6 is also known as RNF89.
