TRIM59
Description
The TRIM59 (tripartite motif containing 59) is a protein-coding gene located on chromosome 3.
TRIM59 is an E3 ubiquitin ligase that plays a role in various cellular processes, including development and immune response. It acts as a negative regulator of innate immune signaling by inhibiting the activation of IRF3/7 and NF-kappa-B, which are triggered by the RLR pathway. TRIM59 interacts with the adapter ECSIT to achieve this suppression. Furthermore, TRIM59 regulates autophagy by controlling both the transcription and ubiquitination of BECN1. It downregulates BECN1 transcription by suppressing the NF-kappa-B pathway. TRIM59 also influences the ubiquitination of BECN1 through TRAF6-mediated 'Lys-63' linkage, ultimately impacting the formation of the BECN1-PIK3C3 complex. Additionally, TRIM59 promotes the proteasomal degradation of TRAF6 by mediating its 'Lys-48' linked ubiquitination. TRIM59 also serves as a critical regulator for early embryo development, specifically from the blastocyst stage to gastrula, by modulating F-actin assembly and the 'Lys-63' linked ubiquitination of WASH1.
TRIM59 is also known as IFT80L, MRF1, RNF104, TRIM57, TSBF1.
