TRIM33
Description
The TRIM33 (tripartite motif containing 33) is a protein-coding gene located on chromosome 1.
TRIM33 is a protein encoded by the human gene TRIM33. It belongs to the tripartite motif family, characterized by three zinc-binding domains: RING, B-box type 1 zinc finger, and B-box type 2 zinc finger, along with a coiled-coil region. TRIM33 functions as a transcriptional corepressor and interacts with TRIM24. It acts as a tumor suppressor gene, preventing chronic myelomonocytic leukemia. TRIM33 also regulates the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells. However, it can also act as an oncogene by preventing apoptosis in B-cell leukemias.
TRIM33 acts as an E3 ubiquitin-protein ligase, promoting the ubiquitination, nuclear exclusion, and degradation of SMAD4 through the ubiquitin proteasome pathway. However, it does not decrease the level of endogenous SMAD4. TRIM33 may also function as a transcriptional repressor, inhibiting the transcriptional response to TGF-beta/BMP signaling. It plays a role in cell proliferation and its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor cells. TRIM33 monoubiquitinates SMAD4, inhibiting the SMAD4-dependent TGF-beta/BMP signaling cascade by interfering with the formation of a stable complex between SMAD4 and activated SMAD2/3.
TRIM33 is also known as ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA.
