TRIM31
Description
The TRIM31 (tripartite motif containing 31) is a protein-coding gene located on chromosome 6.
TRIM31 is a protein encoded by the TRIM31 gene in humans. It belongs to the tripartite motif (TRIM) family, characterized by three zinc-binding domains: a RING, a B-box type 1, and a B-box type 2, as well as a coiled-coil region. TRIM31 localizes to both the cytoplasm and the nucleus. While its precise function remains unclear, it has been shown to interact with TRIM23.
TRIM31 is an E3 ubiquitin-protein ligase that plays a key role in regulating antiviral immune responses and inflammation. It achieves this by attaching ubiquitin molecules to specific target proteins. Specifically, TRIM31 promotes the formation of antiviral signaling complexes by ubiquitinating MAVS, a protein involved in sensing viral infections. On the other hand, TRIM31 negatively regulates the NLRP3 inflammasome, a complex involved in inflammation, by promoting the degradation of NLRP3. Additionally, TRIM31 has been implicated in regulating cell growth.
TRIM31 is also known as C6orf13, HCG1, HCGI, RNF.
