TRIM3

Description

The TRIM3 (tripartite motif containing 3) is a protein-coding gene located on chromosome 11.

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene. The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.

== Interactions == TRIM3 has been shown to interact with Actinin alpha 4. TRIM3 binds to and ubiquitinates Estrogen receptor alpha (ERa) leading to receptor's stabilization.

TRIM3 is an E3 ubiquitin ligase that plays a crucial role in neuronal functions, including the regulation of neuronal plasticity, learning, and memory. It participates in other biological processes like innate immunity and cell cycle regulation. As a component of the cytoskeleton-associated recycling or transport complex in neurons, TRIM3 polyubiquitinates gamma-actin, contributing to neuronal plasticity, learning, and memory. It also ubiquitinates the postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling, thereby modulating dendritic spine morphology. TRIM3 positively regulates the motility of the microtubule-dependent motor protein KIF21B. Its RING-dependent E3 ligase activity induces growth arrest through the ubiquitination of CDKN1A. It also positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3, promoting the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes.

TRIM3 is also known as BERP, HAC1, RNF22, RNF97.

Associated Diseases

WES Whole Exome Sequencing