TRIM26

Description

The TRIM26 (tripartite motif containing 26) is a protein-coding gene located on chromosome 6.

TRIM26, also known as Acid finger protein, RING finger protein 95, and Zinc finger protein 173, is a multi-functional protein with a wide range of cellular roles. It acts as an E3 ubiquitin ligase, attaching ubiquitin tags to target proteins, ultimately leading to their degradation. TRIM26 is involved in regulating the immune response, oxidative stress response, viral infection, and various other cellular processes.

TRIM26, also known as Acid finger protein, RING finger protein 95, or Zinc finger protein 173, is an E3 ubiquitin-protein ligase that plays a key role in regulating various cellular processes, including the immune response, oxidative stress response, and viral infection. It is involved in the production of IFN-beta and the antiviral response by regulating DNA-encoded pattern-recognition receptors (PRRs). TRIM26 also controls the levels of DNA glycosylases NEIL1, NEIL3, and NTH1, which are involved in repairing damaged DNA, thereby influencing the response to oxidative stress. Furthermore, TRIM26 promotes the ubiquitination and proteasomal degradation of IRF3, a transcription factor involved in type I interferon signaling. It also bridges together TBK1 and NEMO during the innate response to viral infection, leading to the activation of TBK1. TRIM26 further regulates the LPS-mediated inflammatory innate immune response by catalyzing the ubiquitination of TAB1, enhancing its activation and subsequent NF-kappa-B and MAPK signaling. Notably, TRIM26 also inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, protecting SOX2 from degradation. Moreover, TRIM26 ubiquitinates PHF20, a component of the histone acetyltransferase protein complex, triggering its degradation in the nucleus. It also ubiquitinates TAF7, a component of the TFIID complex, for proteasomal degradation upon induction by TGF-beta. TRIM26 has been implicated in inducing ferroptosis by ubiquitinating SLC7A11, a protein critical for scavenging lipid reactive oxygen species (ROS). Additionally, TRIM26 inhibits hepatitis B virus replication by mediating HBX ubiquitination and degradation. {ECO:0000250|UniProtKB:Q99PN3, ECO:0000269|PubMed:23452852, ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:29203640, ECO:0000269|PubMed:29610152, ECO:0000269|PubMed:34017102, ECO:0000269|PubMed:34732716, ECO:0000269|PubMed:35872575, ECO:0000269|PubMed:36232914}

TRIM26 is also known as AFP, RNF95, ZNF173.

Associated Diseases

WES Whole Exome Sequencing