TREML1

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Description

The TREML1 (triggering receptor expressed on myeloid cells like 1) is a protein-coding gene located on chromosome 6.

TREML1 is a protein encoded by the TREML1 gene in humans. It is located on chromosome 6 within a gene cluster that includes the activating receptors TREM1 and TREM2, which also have single Ig variable (IgV) domains. Despite its location within this cluster, TREML1 exhibits unique structural and functional characteristics.

TREML1 is a cell surface receptor that potentially contributes to both the innate and adaptive immune responses.

TREML1 is also known as GLTL1825, PRO3438, TLT-1, TLT1, dJ238O23.3.

Associated Diseases

• Parkinson disease
• Glanzmann thrombasthenia 1
• Bernard-Soulier syndrome
• thrombocytopenia 7
• beta-thalassemia-X-linked thrombocytopenia syndrome
• bleeding disorder, platelet-type, 24
• platelet-type bleeding disorder 18
• platelet-type bleeding disorder 15
• von Willebrand disease 3
• platelet-type bleeding disorder 11
• platelet-type bleeding disorder 17
• gray platelet syndrome
• hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1