TRABD2B
Description
The TRABD2B (TraB domain containing 2B) is a protein-coding gene located on chromosome 1.
TRABD2B is a metalloprotease that negatively regulates the Wnt signaling pathway. It achieves this by cleaving the first 8 amino acids from the N-terminal end of specific Wnt proteins. This cleavage triggers oxidation of the Wnt proteins, causing them to form large, inactive oligomers linked by disulfide bonds. TRABD2B can cleave WNT3A and WNT5, but not WNT11. This protein is crucial for proper head development.
TRABD2B is also known as TIKI2.
