TPSG1
Description
The TPSG1 (tryptase gamma 1) is a protein-coding gene located on chromosome 16.
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme produced by the human TPSG1 gene. Tryptases belong to a group of enzymes called serine proteases, which break down proteins. They are only active when they form a group of four molecules held together by heparin, a substance found in the body. Tryptases are unique because they are resistant to breakdown by other enzymes. The TPSG1 gene is part of a cluster of genes on chromosome 16 that produce different types of tryptases. There are four main types: alpha I, beta I, beta II, and gamma I. Beta tryptases are found mostly in mast cells, while alpha tryptases are found mostly in basophils, both types of immune cells. The TPSG1 gene is different from other tryptase genes because it has a special section at the end of its structure that helps it attach to cell membranes. Tryptases have been linked to conditions like asthma and other allergies and inflammatory diseases.
TPSG1 is also known as PRSS31, TMT, trpA.
