TPM3 : tropomyosin 3

Description

The TPM3 (tropomyosin 3) is a protein-coding gene located on chromosome 1.

The TPM3 gene provides instructions for making slow muscle alpha (α)-tropomyosin, a protein belonging to the tropomyosin family. Tropomyosin proteins regulate muscle fiber tensing (contraction) by controlling the binding of myosin and actin, two crucial muscle proteins. In non-muscle cells, tropomyosin proteins are involved in regulating cell shape. Slow muscle α-tropomyosin is specifically found in type I fibers of skeletal muscles, which are responsible for movement. Type I fibers are resistant to fatigue and are the primary component of muscles involved in maintaining posture, like the neck muscles holding the head steady. Slow muscle α-tropomyosin plays a key role in regulating muscle contraction within type I skeletal muscle fibers.

TPM3 binds to actin filaments in both muscle and non-muscle cells. It plays a critical role in regulating vertebrate striated muscle contraction, working in conjunction with the troponin complex and dependent on calcium levels. In smooth muscle, it interacts with caldesmon to regulate contraction. Within non-muscle cells, TPM3 is involved in stabilizing cytoskeletal actin filaments.

TPM3 is also known as CAPM1, CFTD, CMYO4A, CMYO4B, CMYP4A, CMYP4B, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPM3nu, TPMsk3, TRK, hscp30.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing