TPM1


The TPM1 gene encodes a protein called tropomyosin alpha-1 chain, a key player in muscle movement. Tropomyosin acts like a molecular on/off switch within muscle cells, regulating the interaction between actin and myosin, the proteins responsible for contraction. Mutations in TPM1 are linked to various heart conditions, including thickening (hypertrophic cardiomyopathy) or weakening (dilated cardiomyopathy) of the heart muscle.

Associated Diseases

Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Left ventricular noncompaction cardiomyopathy

Did you Know

HCM, caused by mutations in TPM1 and other genes, can sometimes be a silent condition. Even without noticeable symptoms, early detection through genetic testing or cardiac screening is crucial. This allows for better management of the condition and potentially reduces the risk of complications like heart failure or sudden cardiac death.

 

 


Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.