TP53BP2
Description
The TP53BP2 (tumor protein p53 binding protein 2) is a protein-coding gene located on chromosome 1.
TP53BP2, also known as ASPP2 (Apoptosis-stimulating of p53 protein 2), Bbp (Bcl2-binding protein), and NY-REN-51, is a protein encoded by the TP53BP2 gene in humans. It plays a crucial role in regulating apoptosis and cell growth through its interactions with other proteins. TP53BP2 enhances the DNA binding and transactivation function of TP53, promoting apoptosis. It also inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, thereby reducing NAE1's apoptotic activity. TP53BP2 interacts with various proteins, including TP53, BCL2, RELA, and DDX42, affecting its function in regulating apoptosis and cell growth.
TP53BP2 regulates TP53 by enhancing its DNA binding and transactivation function on the promoters of proapoptotic genes, promoting apoptosis. It also inhibits NAE1's ability to induce apoptosis by interfering with NEDD8 conjugation to CUL1. TP53BP2 impedes cell cycle progression at the G2/M checkpoint. Its apoptosis-stimulating activity is suppressed by its interaction with DDX42.
TP53BP2 is also known as 53BP2, ASPP2, BBP, P53BP2, PPP1R13A.
Associated Diseases
- ovarian cancer
- esophageal cancer
- endometrial cancer
- urinary bladder cancer
- epidermodysplasia verruciformis
- acute kidney failure
