TNRC6C-AS1
TNRC6C-AS1 Gene: An Intriguing Player in Human Health and Disease
Description
TNRC6C-AS1 is a long non-coding RNA (lncRNA) located on chromosome 1q32.1 in humans. LncRNAs are a class of RNA molecules that do not code for proteins but play crucial roles in gene regulation. TNRC6C-AS1 is highly expressed in various tissues, including the brain, heart, and liver. It has been implicated in a range of biological processes, including cell proliferation, apoptosis, and immune response.
Associated Diseases
Dysregulation of TNRC6C-AS1 expression has been linked to several human diseases, including:
- Cancer: TNRC6C-AS1 is overexpressed in many types of cancer, including lung, breast, and colon cancer. It has been found to promote cancer cell growth, migration, and invasion.
- Neurological disorders: TNRC6C-AS1 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Studies suggest that it may contribute to neuronal damage and cognitive decline.
- Cardiovascular disease: TNRC6C-AS1 is involved in regulating heart function and blood pressure. Dysregulation of TNRC6C-AS1 expression has been associated with hypertension and heart failure.
- Immune disorders: TNRC6C-AS1 plays a role in immune cell activation and differentiation. Its dysregulation has been linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Did you Know ?
- A large-scale study involving over 10,000 individuals found that a genetic variant in the TNRC6C-AS1 gene was strongly associated with an increased risk of developing lung cancer. This variant was particularly prevalent in smokers, suggesting that TNRC6C-AS1 may play a role in the development of smoking-related lung cancer.
