TNIP2
Description
The TNIP2 (TNFAIP3 interacting protein 2) is a protein-coding gene located on chromosome 4.
TNIP2 is a protein encoded by the TNIP2 gene in humans. It has multiple sites that undergo phosphorylation and ubiquitination.
TNIP2 inhibits NF-kappa-B activation by preventing RIPK1 from interacting with NEMO/IKBKG. It forms a complex with NFKB1 and MAP3K8, playing a role upstream of MAP3K8 in the TLR4 signaling pathway, regulating MAP3K8 activation. TNIP2 activates the MEK/ERK signaling pathway during innate immune responses, though this function is specific to certain stimuli and cell types. It is essential for MAP3K8 stability. TNIP2 participates in regulating apoptosis in endothelial cells, promoting survival stimulated by TEK agonists. It may act as a transcriptional coactivator when moved to the nucleus. TNIP2 enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
TNIP2 is also known as ABIN2, FLIP1, KLIP.
