TNIP1
Description
The TNIP1 (TNFAIP3 interacting protein 1) is a protein-coding gene located on chromosome 5.
TNFAIP3-interacting protein 1, also known as ABIN-1, is a protein that in humans is encoded by the TNIP1 gene.
== Association with autoimmune diseases == Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:
Systemic Sclerosis; Psoriasis; Psoriatic arthritis; Systemic Lupus Erythematosus Type-1 autoimmune hepatitis Lupus nephritis TNIP1 dysfunction or deficiency contributes to hyperinflammarion and may predispose healthy cells to the inflammatory response to otherwise innocuous TLR ligand exposure.
== Association with neurodegenerative diseases == A recent genome-wide association study (GWAS) has found that genetic variations in TNIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD).
== Interactions == TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated, and has been shown to interact with TNFAIP3, MAP3K1, and MAPK1.
== Regulation == TNIP1 was shown to be part of a transcription module controlled by BCL3. BCL3 gen was found to be strongly associated with Aβ42 after conditioning for APOE and was found as upregulated in the brain of patients with LOAD.
== References ==
== Further reading ==
== External links == TNIP1 human gene location in the UCSC Genome Browser. TNIP1 human gene details in the UCSC Genome Browser.
TNIP1 inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG. It links A20/TNFAIP3 to ubiquitinated IKBKG. TNIP1 is involved in regulating the EGF-induced ERK1/ERK2 signaling pathway by blocking MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. It increases cell surface CD4(T4) antigen expression. TNIP1 plays a role in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. It is involved in the prevention of autoimmunity, likely through its binding to polyubiquitin. TNIP1 is involved in leukocyte integrin activation during inflammation through its association with SELPLG and phosphorylation by SRC-family kinases. It interacts with HIV-1 matrix protein, is packaged into virions, and overexpression can inhibit viral replication. It may regulate matrix nuclear localization, including nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. During bacterial infection, TNIP1 promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p, which leads to polyubiquitination of IKBKG and its proteasome-dependent degradation, perturbing NF-kappa-B activation.
TNIP1 is also known as ABIN-1, NAF1, VAN, nip40-1.
