TNFRSF1A


Description

The TNFRSF1A gene, located on chromosome 12, encodes the tumor necrosis factor receptor superfamily, member 1A (TNFR1). TNFR1 is a transmembrane protein that plays a crucial role in the immune system by binding to the cytokine tumor necrosis factor-alpha (TNF-alpha). This interaction triggers a signaling cascade that regulates various cellular processes, including inflammation, apoptosis, and cell survival. TNFR1 is involved in a wide range of physiological and pathological processes, and its dysregulation can contribute to the development of several diseases.

Associated Diseases

Did you know?

Mutations in the TNFRSF1A gene have been linked to a rare genetic disorder called TNF receptor-associated periodic syndrome (TRAPS), characterized by recurrent episodes of fever, inflammation, and pain.


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