TNFRSF10B

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Description

The TNFRSF10B gene, also known as TRAIL-R2 or DR5, encodes a type I transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily. It plays a crucial role in regulating apoptosis, inflammation, and immune responses. TNFRSF10B binds to its ligand, TRAIL (TNF-related apoptosis-inducing ligand), triggering a signaling cascade that leads to the activation of caspases and subsequent cell death. This pathway is essential for maintaining immune homeostasis and eliminating unwanted or damaged cells. TNFRSF10B has also been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

Associated Diseases

• Cancer (e.g., colorectal cancer, breast cancer, lung cancer)
• Autoimmune diseases (e.g., rheumatoid arthritis, inflammatory bowel disease)
• Neurodegenerative diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)

Did you know?

TNFRSF10B is highly expressed on cancer cells, making it an attractive target for cancer therapy.