TMX2-CTNND1
Description
The TMX2-CTNND1 (TMX2-CTNND1 readthrough (NMD candidate)) is a ncRNA gene located on chromosome 11.
The TMX2-CTNND1 fusion gene is an abnormal gene produced by a chromosomal rearrangement. This fusion gene leads to the creation of a new protein that contains parts of both the TMX2 and CTNND1 genes. This fusion protein may disrupt the normal function of the original genes, potentially contributing to cancer development.
The TMX2-CTNND1 fusion protein, resulting from a chromosomal translocation, disrupts the normal function of both the TMX2 and CTNND1 genes. This fusion protein lacks the transmembrane domain of TMX2 and the catenin-binding domain of CTNND1, leading to aberrant protein interactions and signaling pathways. Specifically, the fusion protein can interfere with cell adhesion and signaling pathways involved in cell growth and proliferation.
TMX2-CTNND1 is also known as CAS, CTNND1, p120(cas), p120(ctn).
