TMPRSS4

Description

The TMPRSS4 (transmembrane serine protease 4) is a protein-coding gene located on chromosome 11.

TMPRSS4 is a human gene that encodes a member of the serine protease family. These proteases are involved in various biological processes, and their dysfunction can lead to diseases and disorders. TMPRSS4 was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane-bound, with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.

TMPRSS4 is also known as CAP2, CAPH2, MT-SP2, TMPRSS3.

Associated Diseases

• autosomal recessive cerebral atrophy
• cancer
• breast cancer
• lung neoplasm
• Treacher-Collins syndrome
• pachyonychia congenita
• pancreatic ductal adenocarcinoma
• COVID-19