TMOD1

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Description

The TM6SF2 gene provides instructions for making a protein called transmembrane 6 superfamily member 2. This protein plays a crucial role in regulating lipid metabolism, particularly in the liver. It helps control the production and breakdown of fats, including triglycerides and cholesterol. Variations in the TM6SF2 gene have been linked to a range of liver diseases, making it a significant focus in genetic research.

Associated Diseases

• Non-alcoholic fatty liver disease (NAFLD)
• Non-alcoholic steatohepatitis (NASH)
• Hepatic steatosis
• Hepatic fibrosis
• Cirrhosis
• Liver cancer

Did you know?

A common genetic variant in the TM6SF2 gene, rs58542926, is associated with lower risk of developing severe liver disease. This variant is more prevalent in certain populations, explaining variations in disease susceptibility.