TMEM98
Description
The TMEM98 (transmembrane protein 98) is a protein-coding gene located on chromosome 17.
Transmembrane protein 98 is a single-pass membrane protein encoded by the TMEM98 gene in humans. Its function is not fully understood. TMEM98 is also known as UNQ536/PRO1079.
The TMEM98 gene is located on the plus strand of chromosome 17 at locus 17q11.2, spanning from base pairs 31,254,928 to 31,272,124.
Two known transcript variants encode for TMEM98. Variant one is longer, has 8 exons, and is 1808 bases in length. Variant two codes for the same protein but is shorter, missing exon 3 and part of exon 2, resulting in a length of 1732 bases. The missing region corresponds to 85 base pairs near the end of the 5' UTR. Variant one is more abundant than Variant two, with 17 times the amount of mRNA extracted in various human tissue experiments.
There are no known paralogs for TMEM98.
TMEM98 acts as a negative regulator of MYRF in the process of oligodendrocyte differentiation and myelination. It interacts with the C-terminal end of MYRF, inhibiting MYRF's self-cleavage and the movement of its N-fragment into the nucleus. Furthermore, the secreted form of TMEM98 encourages the differentiation of T helper 1 cells (Th1).
TMEM98 is also known as TADA1.
