TMEM82
Description
The TMEM82 (transmembrane protein 82) is a protein-coding gene located on chromosome 1.
TMEM82 is a protein encoded by the TMEM82 gene in humans. The TMEM82 gene is found on chromosome 1 (1p36.21) from 15,742,499 to 15,747,982, spanning 5,484 base pairs. It is found on the plus strand and has 6 exons and 5 introns. The SLC25A34 gene is found on TMEM82's antisense strand and ecodes for a mitochondrial carrier protein. There are a few known genetic variants which alter the molecular phenotype. One is an intergenic mutation that results in a protein product that is associated with Troponin-T. A SNP (T/C, missense) with an allele frequency of about 4% results in a protein product that is associated with Insulin-Like Growth Factor Binding Protein 3, although with a very small effect size. There human mRNA transcript for TMEM82, of which there are no isoforms, has 1,443 nucleotides which encodes a 343 amino acid long precursor protein of about 37kDa including 8 predicted transmembrane domains and 1 disordered region. In humans, the RNA transcript is expressed highly in the kidney, liver, small intestine, and duodenum and is also expressed in the colon and stomach. Single cell RNA-seq data indicate several tissue specific cell types with enhanced TMEM82 expression in the stomach, colon, kidney, and liver: these cell types include parietal cells, chief cells, gastric mucous cells, mitotic cells, and gastric enteroendochrine cells in the stomach, colon enterocytes in the colon, proximal tubular cells in the kidney, and hepatocytes in the liver. During fetal development it is also expressed in adrenal and heart tissues and becomes highly expressed in the small intestine by 15 weeks of gestation.
TMEM82, also known as Transmembrane protein 82, is a protein encoded by the TMEM82 gene. It is located on chromosome 1 and spans 5,484 base pairs. The gene has 6 exons and 5 introns. TMEM82's mRNA transcript is 1,443 nucleotides long and encodes a 343 amino acid precursor protein with an approximate molecular weight of 37 kDa. This protein contains 8 predicted transmembrane domains and 1 disordered region. TMEM82 expression is particularly high in the kidney, liver, small intestine, and duodenum. It is also expressed in the colon and stomach. Single-cell RNA sequencing data reveals enhanced TMEM82 expression in specific cell types within these organs, including parietal cells, chief cells, gastric mucous cells, mitotic cells, and gastric enteroendochrine cells in the stomach; colon enterocytes in the colon; proximal tubular cells in the kidney; and hepatocytes in the liver. During fetal development, TMEM82 expression is observed in adrenal and heart tissues, with significant upregulation in the small intestine by 15 weeks of gestation. There are a few known genetic variants that alter the molecular phenotype. One variant results in a protein product associated with Troponin-T. Another SNP (T/C, missense) with an allele frequency of about 4% leads to a protein product associated with Insulin-Like Growth Factor Binding Protein 3, although with a very small effect size.
TMEM82 is also known as -.
