TMEM41B
Description
The TMEM41B (transmembrane protein 41B) is a protein-coding gene located on chromosome 11.
TMEM41B is a transmembrane protein that acts as a phospholipid scramblase. It is involved in lipid homeostasis, membrane dynamics, and autophagosome formation. It is also a key host factor for the replication of various viruses, including coronaviruses and flaviviruses.
TMEM41B, also known as Stasimon, acts as a phospholipid scramblase, playing a crucial role in maintaining lipid homeostasis and regulating membrane dynamics. It exhibits scramblase activity towards various phospholipids, including cholesterol, phosphatidylserine, phosphatidylethanolamine, and phosphatidylcholine. TMEM41B is essential for autophagosome formation, participating in the early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane. It redistributes lipids across the ER membrane leaflets as ATG2 (ATG2A or ATG2B) removes lipids, ultimately facilitating autophagosome assembly. TMEM41B's functions extend beyond autophagy, involving other processes requiring phospholipid scramblase activity. Moreover, it is crucial for normal motor neuron development.
TMEM41B is also known as -.
Associated Diseases
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- homozygous familial hypercholesterolemia
- pancreatic triacylglycerol lipase deficiency
- sitosterolemia
- thyroid hormone metabolism, abnormal, 2
- hyperlipidemia due to hepatic triglyceride lipase deficiency
- COVID-19
- cancer
- Zika virus infectious disease
